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In STEP-1 (N=1,961), semaglutide 2.4 mg produced nausea in 44.2% of participants versus 16.0% on placebo, and eructation was reported at roughly 9.9% on semaglutide versus 3.7% on placebo at 68 weeks [1]

However, their FDA approvals diverge significantly

If it eventually makes its way onto the list of the prohibited substances, we will be forced to recommend everyone against drinking coffee as well as soft drinks containing caffeine. (Washington Post) Caffeine was added to WADAs monitoring program for 2017 so experts could study whether athletes are using the substance with the intent of enhancing performance. The studies will continue through September, at which point WADA would issue a 3-month notice for substances set to then be added to the Prohibited List the following year, a la the process experienced with meldonium in late 2015

J Neurotrauma 28:20912102 Boggs RC, Watts LT, Fox PT, Clarke GD (2024) Metabolic diaschisis in mild traumatic brain injury