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Erastin blocks cystine uptake, depleting glutathione and inactivating glutathione peroxidase 4 (GPX4), the enzyme responsible for detoxifying phospholipid hydroperoxides

Abstract The transsulfuration (TSS) pathway is an alternative source of cysteine for glutathione synthesis

These findings demonstrate that ROS exert a direct effect in mediating bronchial responsiveness and asthma

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