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If left untreated, it can lead to Heart palpitations and shortness of breath Weakness, tiredness, or lightheadedness Pale skin Vision loss Constipation, diarrhea, loss of appetite, or gas A smooth tongue Depression Memory loss Behavioral changes Numbness or tingling Muscle weakness Problems walking not trying to give you the wobbles here!), low levels of B12 can be linked to the development of pernicious anemia, dementia, or osteoporosis

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In the gut-brain axis, unique neural pathways like vagus nerve signaling and serotonin modulation influence neurodegeneration, differing from the gut-liver axiss portal vein transport of bile acids and LPS, affecting FXR/TGR5 for lipid homeostasis in NAFLD