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They are 463 amino acid heptahelical G protein-coupled receptors that, when activated, stimulate cyclic adenosine monophosphate (cAMP) formation followed by activation of protein kinase A pathways [20]

Dihexas positioning is specifically through the HGF/c-Met receptor system with downstream PI3K/AKT signaling and dendritic spinogenesis as the major in vitro readout

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