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One weekly injection may be all you need, but when it comes to optimizing the value of GLP-1s, thats not all there is to it
In a meta-analysis 6 of eight trials with 60080 patients (ELIXA, LEADER, SUSTAIN-6, EXSCEL, Harmony Outcomes, REWIND, PIONEER 6, and AMPLITUDE-O) , treatment with a GLP-1 receptor agonist led to a 14% relative risk reduction in three-point MACE (HR 086 [95% CI 080093]
While semaglutide focuses on one pathway, tirzepatide is a dual-action agonist , meaning it activates two different hormone receptors, not just one
Key Takeaways Tirzepatide targets two hormones (GLP-1 and GIP)
![F/35/5'7 [254lbs > 164lbs = 90lbs] (1 year) Semaglutide and strength training. 4lbs away from goal! : r/progresspics](https://preview.redd.it/f-35-57-254lbs-164lbs-90lbs-1-year-semaglutide-and-strength-v0-t0k870b8hnfe1.jpeg?width=640&crop=smart&auto=webp&s=a87464607a1fafb4d422303c90e71f49b6cda2b4)
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