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139 CDC42, a master regulator of epithelial cell polarity, is activated by TUBA, an apically localized guanine nucleotide exchange factor (GEF) for CDC42, and positively regulates the activity of aPKC to promote apical membrane identity and the formation of adherens junctions, and to control vesicle trafficking 6,119,129,140,141 (Figure 3(a))

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Specifically, the researchers observed a 15% reduction in the risk of developing nonexudative AMD and a 20% decrease in the incidence of exudative AMD compared to those receiving alternative diabetes therapies