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Participants were randomised 3:1 to receive MEDI4166 or placebo using an interactive voice/web response system, which blinded all participants, investigators and study site personnel to the study drug administered

The table lists a history of pancreatitis as a relative contraindication, chronic diarrhea or IBS as symptoms that may worsen, elevated liver enzymes as requiring baseline labs, and a family history of medullary thyroid cancer as an absolute contraindication under FDA labeling

Others might switch to an equivalent high-quality oral B-complex once their gut can absorb again

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