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Lipids induce the dysfunction of lysosomes in mice macrophages, as shown by an increase in lysosomal pH, decrease in proteolytic ability, and destruction of membrane integrity 24
ACPAs production is typically triggered by environmental factors and epigenetic changes, which often involve a combination of genetic and environmental influences (47)
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doi: 10.3389/fphar.2020.579944 Received 03 July 2020 Accepted 15 September 2020 Published 07 October 2020 Volume 11 - 2020 Edited by Leonello Fuso, Catholic University of the Sacred Heart, Italy Reviewed by Stephen C
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