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A 2021 peer-reviewed review of NNMT in obesity and type 2 diabetes states explicitly that 'clinical trials targeting NNMT have not been reported' meaning every quantitative efficacy figure available for this compound comes from mice, and there is currently zero published human efficacy data

Some practitioners theorize that local administration to abdominal fat may enhance regional lipolytic effects, though this has not been conclusively proven

They're excellent for body recomposition - losing fat while gaining muscle simultaneously