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In vivo , Sirt1 protein expression was also significantly decreased in the livers of mice by NNMT knockdown [14]

Effects of NNMT inhibitors on 3T3-L1 cell viability The cytotoxic effects of three membrane-permeable NNMT inhibitors, 5-amino-1MQ, 7-amino-1MQ, and 2,3-diamino-1MQ were evaluated in 3T3-L1 pre-adipocytes

These findings position 5-Amino-1MQ as a promising subject in the broader context of research on metabolic longevity and cellular optimization

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