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Importantly, these increases did not correlate with serious adverse cardiovascular events in the trial populations, and heart rate typically returned toward baseline levels as treatment continued beyond the dose-escalation phase

Pooled analysis reported statistically significant effect on hypoglycemia outcomes from treatment with GLP-1RA versus placebo [RR=0.70, 95% CI (0.57, 0.87), p =0.001], showed that the risk of hypoglycemia was about 30% lower in the GLP-1RA treatment group than the placebo group

We collected data from animal studies in a blinded manner and performed the final statistical analysis

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