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In the STEP 1 extension study, participants who stopped semaglutide after treatment regained a substantial portion of the weight they had lost during the following year, and cardiometabolic improvements moved back toward baseline

Under physiological conditions, natural GLP-1 is secreted by the intestines in response to food intake, prompting insulin release and managing glucose levels

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I just didn't care." The Biology: Your GLP-1 receptors in the hypothalamus are now getting consistent stimulation