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This dual-faceted ranking method successfully identified compounds with both high computational and experimental inhibitory activity, demonstrating the enhanced reliability of integrating diverse data sources

However, the more honest metric is cost per effective dose , and here oral's lower and more variable systemic bioavailability complicates the picture: if a larger oral dose is needed to achieve a comparable systemic effect, the apparent per-milligram savings shrink

Dose adjustments during maintenance depend on individual response

This one instance where one would need a lifetime treatment of vitamin B12 injections