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Tumor suppression in humans relies on the immune system, but metastatic tumor cells can evade immune detection by using checkpoints like CTLA-4 and PD-1/PD-L1, thereby inhibiting immune responses and weakening anticancer immunity.This version simplifies and streamlines the information for better readability and clarity ( + tumor-infiltrating T cells enhance the expression of PD-1 and CTLA-4 in patients with pancreatic ductal adenocarcinoma (PDAC) (Wartenberg et al., 2018)

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