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These differences manifest in sexbiased neurodegeneration pathologiespostmenopausal females show 2fold higher Alzheimer's incidence (linked to estrogen loss and APOE4tau interactions), whereas males have 1.5fold greater Parkinson's risk (associated with iron accumulation in substantia nigra) [156]

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Supplementary Materials Data Availability Statement All data generated or analyzed during this meta-analysis are derived from peer-reviewed publications, as detailed in the references.

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