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347 AT-rich interacting domain 1 A (ARID1A), an important subunit of the chromatin remodeling complex, carries a heterozygous mutation in most human GC cases, and tumor organoids with ARID1A heterozygosity show growth inhibition by combination therapy with TP06 and Nutlin-3, an epigenetic inhibitor and a p53 agonist, respectively, offering a new option for GC therapy

Novo Nordisks blockbuster product, Ozempic, a GLP-1 agonist, has revolutionized both diabetes and weight management treatments

More recently, encouraging clinical results from a triple-hormone-receptor agonist, Retatrutide, and several GLP-1R/GCGR dual agonists, suggest that GCGR could be a promising co-stimulating target for type 2 diabetes and obesity.

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