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Early pharmaceutical development efforts, therefore, prioritized selective MC4R agonism over MC3R, a decision guided by rodent studies utilizing genetic data, knockout models, and studies with melanocortin ligands
Binary or categorical outcome variables were analyzed using 2 -test for comparison of genders in the two groups: 2x5 contingency 2 was used for comparison of the choice of food after placebo or GLP-1 infusion, and 2x2 contingency 2 was used for comparison of genders according to response to placebo or GLP-1 infusion
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