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Single-cell analysis of Crohns disease lesions identifies a pathogenic cellular module associated with resistance to anti-TNF therapy

Compared to popular GLP-1RAs like semaglutide, orforglipron does not require injection or an absorption enhancer with fasting to achieve exposure, and it can be taken without water or food restrictions, according to Phase 1 pharmacokinetic data

A 10mg/mL concentration covers weeks 1-16 but cannot practically deliver the 12mg maintenance dose