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For example, if a beneficiary initiated GLP-1 therapy in September 2024 with a body mass index (BMI) of 37 and has a BMI of 34 at the time of a July 2026 prior authorization request, the prescribing provider should attest that the beneficiary met the BMI 35 criterion at the time therapy was initiated

Call 999 or attend A&E immediately for severe abdominal pain (possible pancreatitis), sudden eye pain or vision changes, or signs of severe dehydration

Better blood sugar control in people with diabetes or prediabetes

Additionally, IGF-1 stimulates the synthesis of neuronal RNA and promotes the formation of axons, the long projections of neurons that transmit nerve signals (Dyer et al., 2016)