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28 Kidney Issues: While some GLP-1s have shown kidney-protective benefits, certain GLP-1s may not be appropriate for individuals with pre-existing severe kidney disease

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SREBP is frequently upregulated in various cancers, potentially through tumor cell-expressed Programmed Cell Death Ligand 1, which activates the EGFR/integrin subunit 4/SREBP1c signaling axis, thereby driving lipid metabolic reprogramming and supporting tumor progression [22, 216]

68 In later ages, strategies to cope with their longing for food, their asking for more food, and their food seeking behavior should be individually developed, taking into account that PWS individuals require fewer calories (40%70% reduction) compared with nonobese controls