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Subsequently, trials like Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction (DAPA-HF) [10] and Dapagliflozin in Heart Failure with Mildly Reduced or Preserved Ejection Fraction (DELIVER) [13] for dapaglifozin, as well as the Cardiovascular and Renal Outcomes with Empagliflozin in Heart Failure (EMPEROR-Reduced) [14] the Empagliflozin in Heart Failure with a Preserved Ejection Fraction (EMPEROR-Preserved) [15] trials for empaglifozin, have demonstrated a reduction in CV events regardless of LV ejection fraction (EF) and the presence of DM2

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Confirmation by in vivo biochemical findings