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Briefly, urine samples (500 l), HepaRG cell and hepatocyte samples (300 l), and microbiota samples (150 l) were diluted to 1 ml of HPLC grade water, acidified with 1% formic acid and extracted using Strata-X SPE

The infected cells can migrate to the spinal cord and induced the HAM/TSP development

Notably, Arg1 expression in MDSCs contributes to arginine depletion in the microenvironment, further inhibiting T-cell antitumor function and reducing their survival

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