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Future endeavors should concentrate on merging advancements in multi-omics technologies to monitor interindividual metabolic variabilities, emphasizing early diagnosis and personalized therapeutic strategies

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It plays a significant role in promoting moderate mitochondrial stress, which activates Nrf2, adenosine 5-monophosphate-activated protein kinase (AMPK), and SIRT1 and SIRT3, all of which are involved in anti-inflammatory and antioxidant responses (188)

HepG2 cells are treated with AMPK inhibitor (CC, 20 M, 0.5 h), SIRT1 inhibitor (NA, 10 mM, 12 or 24 h), and AMPK activator (AICAR, 2 mM, 1 h), Palmitate (PA, 125 M, 12 h) and -Lipoic Acid (250 M, 6 or 12 h) [1]