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For example, RNA sequencing analyses of human and murine osteoblasts and osteoclasts confirmed gene expression of all dopamine receptors and showed increased expression of Drd1, Drd2, and Drd3 during osteoclastogenesis, while mouse osteoblast precursors and mature osteoblasts expressed higher levels of Drd3 and Drd4 (Handa et al., 2019)

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Ecogeographically distinctive regions including the Qinghai-Tibetan Plateau, Andean Highlands, and Rocky Mountains have become focal areas for altitude-associated health research

Initial studies reported that GABA was unable to cross the BBB