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The semaglutide component has an established safety profile from over 7 years of post-marketing experience

The Switching Protocol If switching from semaglutide to tirzepatide: Take your last dose of semaglutide as scheduled Wait one week (your normal injection day) Start tirzepatide at the initial dose recommended by your provider Follow the prescribed titration schedule Start tirzepatide at the dose recommended by your provider, even if you were on a higher dose of semaglutide

In research contexts, peptides targeting different inflammatory mechanisms are sometimes studied together