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Both of these peptides are rapidly degraded by the enzyme DPP-4, which is expressed in a number of sites, including the endothelial cells of small gut arterioles

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Reasons for increased needs in athletes: stress related to physical demands (Yes, training is stress on the body!) biological adaptations increased turnover (athletes use more vitamins) genetics reduced absorption Early detection of deficiency can be difficult to recognize because symptoms overlap with many other conditions and are normalized in athletes