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Regulation of GPX4 expression includes multiple mechanisms, such as gene transcription and post-translational modification, which significantly affect the level of lipid peroxidation in tissue damage

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The systematic analysis found that cartilage lesions complicated by limited progenitor cell activity and healing capacity, large size, high mechanical demands, local and systemic inflammation, or other systemic diseases are often excluded from treatment, likely due to complications and poor outcomes after cartilage restoration procedures in this context

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