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ARID1A directly binds the Foxa2 promoter to regulate its transcription, and reduced ARID1A correlates with decreased FOXA2 in both human and non-human primate endometriosis models ( DNA methylation modifiers, including DNA methyltransferases (DNMT1, DNMT3A, DNMT3B) and ten-eleven translocation (TET) methylcytosine dioxygenases (TET1, TET2, TET3), show altered expression in endometriosis, though findings may vary due to sample heterogeneity (cell types, menstrual cycle phases)

6 Clinical trials of natural metabolites for the treatment of EMs The potential therapeutic efficacy of natural metabolites has been investigated in clinical trials, with some results have confirmed their effectiveness and safety (Table 3)

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