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Semaglutide requires a 2-month washout period before planned pregnancy, and effective contraception is recommended during treatment

More about compounding concerns An open letter from Eli Lilly and Company regarding certain practices related to Mounjaro and Zepbound (June 2024) FDA warns about adverse events from compounded semaglutide (May 2023) Novo Nordisk escalates legal actions to safeguard patients from potentially harmful compounded semaglutide drugs (May 2024) The Center for Medicine in the Public Interest's September 2025 handout explains concerns about mass compounding

Drug compounding occurs when a pharmacy combines raw active ingredients to prepare a medication not commercially available to meet a patients unique needs

SURMOUNT-5, published in the New England Journal of Medicine in 2025, directly compared tirzepatide to semaglutide