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As PA without treatment can lead to various symptoms with irreversible neurological sequelae (Table 3), It is recommended to test for IF antibodies in a patient with suspected cobalamin deficiency [3,7,14]

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This might be associated with a metabolic imbalance, resulting in the accumulation of reactive species, which may be responsible for the premature ageing and tissue damage found in Down syndrome

Your doctor may recommend against this combination if you have: A history of seizures or eating disorders Severe liver or kidney problems Certain heart conditions A history of bipolar disorder Alcohol or substance use disorders Age can also be a factor