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This can result from chronic oxidative stress, heavy metal toxicity (especially iron overload), persistent infections, nutrient insufficiencies (sulfur amino acids, glycine, glutamate, selenium, B-vitamins), liver dysfunction, metabolic stress, and genetic polymorphisms in key enzymes like glutamate-cysteine ligase (GCL) or glutathione S-transferases (GSTs)

doi: 10.1128/JB.00476-18 31 LazarusG

Levine, J., Barak, Y., Gonzalves, M., Szor, H., Elizur, A., Kofman, O., & Belmaker, R

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