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However, because these observations rely solely on immunohistochemistry, they indicate potential involvement rather than providing definitive mechanistic evidence, and molecular validation is required to confirm these pathways

198 A randomized placebo-controlled trial in 50 patients on hemodialysis found that supplementing with a probiotic formulation containing Lactobacillus sporogenes and fructo-oligosaccharides (FOS) (ie, fermentable prebiotic fibers) for eight weeks led to increased hematocrit, hemoglobin, and red blood cell counts, as well as improved markers of iron status