The following comparison summarizes the key considerations: For patients with intact GI absorption, oral high-dose supplementation (1,000 to 2,000 mcg daily) provides a convenient and cost-effective path to correcting deficiency
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Studies show improved outcomes in models of osteoarthritis and joint damage, likely mediated through growth factor upregulation and anti-inflammatory pathways
This keeps vitamin B12 levels up and prevents deficiency from coming back
