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Systematic reviews and comparative analyses suggest the following pattern: Dualagonists such as tirzepatide typically produce more weight loss than GLP1 singleagonists

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Interestingly, the GLP-1 receptor agonist, dulaglutide, and the dual GLP-1 and GIP receptor agonist, tirzepatide, are both characterized by a strong delayed gastric emptying upon a single dose administration, but the effect tends to subside as gastric emptying tachyphylaxis is observed after several weeks of treatment

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