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A single but well done trial of 1,200 mg calcium and 50 meq/d sodium (they actually ate about 120 mEq/d on average) was much more effective in preventing stones than was a low calcium high sodium diet 400 mg/d calcium and uncontrolled sodium which was about 200 mEq a diet that many people may be eating in the US today

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One plausible explanation for these results is that the gpoA mutant is unable to effectively counteract the elevated ROS concentrations encountered within the intracellular environment of host cells, despite the partial compensatory activity of the TpxD and AhpD peroxidases (Fig