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For instance, the total NADP(H) is about 420 nmol/g wet weight in rat liver and 59% of total NADP(H) is found in mitochondria, and 30 nmol/g wet weight in skeletal muscle, 5,8 and the NADPH concentration in the cytosol is 3.1 0.3 and 37 2 M in the mitochondrial matrix in HeLa cells

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Binding to this allosteric site can still influence the sensitivity and activity of the receptor, but could lead to drugs with fewer off-target side-effects, since GLP-1 is involved in many different metabolic signalling pathways