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Because TMG is an osmolyte, it brings water into the cell and takes it out as needed, which in turn helps counteract heat stress and potentially combats the visible effects of skin aging related to hydration.23 24 Cardiovascular health Research indicates that TMG can lower homocysteine, a toxic metabolite associated with cardiovascular risk.18 In a 2003 study, human subjects who received 1.5g, 3g, or 6g of supplemental TMG over six weeks exhibited decreases in their homocysteine levels by 12%, 15%, and 20%, respectively, compared to placebo.25 Another study, the following year, yielded comparable outcomes with roughly similar doses over four weeks.26 Tying these studies together, a 2024 review and meta-analysis concluded that 4g of TMG per day could positively affect cardiovascular markers via homocysteine decrease without adverse effects on lipid profiles.9 Physical strength Methionine is a precursor of creatine, a compound that increases your bodys ability to regenerate adenosine triphosphate (ATP).27 28 ATP is the primary carrier of cellular energy, so an increase in available ATP corresponds to a higher capacity for physical strength performance.29 And because higher levels of TMG lead to larger volumes of circulating methionine, it follows that TMG supplementation can increase your strength potential via elevated serum creatine

& Schellens, J

Table 3 Summary of meta-analysis of cytokines in peripheral blood and cerebrospinal fluid of SZ patients

Kumar et al