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An umbrella review analysing more than 200 meta-analyses in 2017 found that drinking three to four cups of coffee a day was more often linked to health benefits rather than harm, and that studies finding harmful associations could be explained by the higher proportion of coffee drinkers that also smoke

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Animals were housed at 22 2C with 55% 5% relative humidity under a 12 h light/dark cycle and allowed ad libitum access to food and water after a 7-day acclimatization

In all cases, the pharmacokinetic profile will guide dosing and frequency of administration, with the aim to secure high concentration of active antibody in blood and tissue, with as much as possible reaching its target over time