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& Kimura, R

CRTC1 mediates preferential transcription at neuronal activity-regulated CRE/TATA promoters

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They increase the activities of the phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) pathways ( 2 commonly found in areas of rapidly growing solid tumors (32, 33), several enzymes of the glycolytic pathway and the activity of pyruvate dehydrogenase kinase (PDK1), an enzyme that phosphorylates and inactivates the pyruvate dehydrogenase complex that is needed to convert pyruvate to acetyl-CoA (34, 35)