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24,25 Treatment can also reduce lipid storage to protect against the development of fatty liver disease by inhibiting fatty acid synthesis and promoting fatty acid oxidation

In the SURMOUNT and SURPASS trials, nausea affected 17 to 25% of patients (dose-dependent, worst during dose escalation)

Interestingly, while IL-17A has been alluded to as a pathogenic cytokine in ASD, studies have also demonstrated a paradoxical capacity for IL-17A to restore neurotypical behaviors in MIA mice [173, 176]

Recent Findings While GLP- 1 RA can result in total weight loss upwards of 25%, recent studies show that they can also lead to significant loss of lean body mass, reaching as high as 1540% of total weight lost