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These findings imply that MT does not simply act through TRIP13 but rather that MT may suppress TRIP13 expression as part of its mechanism
In addition, PFOS can induce autophagy activation with increased Beclin and LC3BII expression through reactive oxygen species (ROS)-mediated extracellular signalregulated kinase (ERK) activation, which is followed by impeded autophagic flux, increased lysosomal membrane permeability (LMP), and, consequently, RTC apoptosis
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This combination also helps protect against environmental damage and premature aging
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