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The metabolism of every cell in the body depends on vitamin B-12, as it plays a part in the synthesis of fatty acids and energy production

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184 demonstrated that GR24 application upregulated the expression of several SL biosynthetic genes ( PbD27, PbDAD1, PbCYP711 ) and signaling components ( PbD14, PbMAX2A, PbPDR1 ), further supporting the involvement of MAX2 in SL mediated stress responses

It is worth mentioning that in numerous experimental studies Fenton reaction substrates, one of which is H 2 O 2 , are repeatedly confirmed to increase oxidative damage to macromolecules in different tissues (reviewed in, e.g., [151], also [135, 152,153,154,155]), the thyroid gland included [135, 156,157,158,159]