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An Evidence-Based Approach to Anticoagulation Therapy Comparing Direct Oral Anticoagulants and Vitamin K Antagonists in Patients With Atrial Fibrillation and Bioprosthetic Valves: A Systematic Review, Meta-Analysis, and Network Meta-Analysis

| | Intensive Performance Protocol | 10mg subcutaneous, 5x/week (weekdays) | 150mg oral, daily | Both compounds AM, pre-training | 6 weeks on, 4 weeks off | Athletic performance research, substrate utilization studies, endurance capacity trials | Higher dosing frequency and dose intensity produce more pronounced short-term shifts in RER and VO2 max, but require stricter adherence and increase washout sensitivity

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