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As aforementioned, during critical illnesses such as sepsis, the body is in a state of oxidative stress, where factors such as excessive release of inflammatory cytokines, mitochondrial dysfunction, dysregulation of calcium homeostasis, neuropathy and abnormal cell membrane depolarization collectively contribute to muscle protein imbalance

Results: After PSM, each cohort included 350,536 patients (mean age 58.7 12.6 years

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