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In cells, these compounds are possibly yielded by the action of two enzymes: either gamma-glutamyl transferase (-GT) or glutamate cysteine ligase (GCL) ( As these dipeptides contain glutamate in their structure, some of them exhibit high affinity for ionotropic glutamate receptors, including AMPA, kainate, and NMDA receptors (AMPAr, KAr, and ANMDAr), as evidenced recently by binding studies ( In the present study, we aimed first to develop a new, simple, and efficient synthesis of -glutamyl dipeptides and second to characterize their effect on glutamatergic neurotransmission
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