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Most patients experience significant improvement in nausea tolerance by weeks 612 of treatment, even as their doses increase

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Adiponectin also increases the expression of protein tyrosine phosphatase-1B (PTP1B), which enhances SOCS-3 binding to the leptin receptor Ob-Rb, thereby blocking leptin-mediated formation of extracellular TIMP-1/MMP-1 complex [179], thus resulting in anti-fibrotic effects (Fig

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