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The evidence is strongest for reducing the frequency and severity of flare-ups, not for reversing the underlying disease

These interventions, recognized for their ability to modulate oxidative stress and suppress pro-inflammatory cytokines, offer pain relief and functional enhancement in patients with knee OA [3, 43, 44]

Recent data suggest that not only hyperinsulinemia but also excess liver fat are among the main inhibitory influences on SHBG secretion in obese subjects, in a process in which pro-inflammatory cytokines derived from ectopic adipose tissue are likely implicated (213)

[DOI] [PubMed] [Google Scholar] 33.Yusta B., Baggio L.L., Estall J.L., Koehler J.A., Holland D.P., Li H., Pipeleers D., Ling Z., Drucker D.J