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Glutathione: What you should know

Lab Clin Med

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Ferroptosis is a form of programmed cell death driven by iron-dependent lipid peroxidation, characterized by abnormal accumulation of iron and lipid peroxides (lipid ROS) in cells, disrupting REDOX balance and ultimately leading to cell death, mainly caused by loss of glutathione peroxidase (GPX4) activity in cells ( A study on the mechanism by which metformin-induced ferroptosis inhibits the proliferation of breast cancer cells found that metformin can increase intracellular Fe2+ and lipid ROS levels, and can also induce ferroptosis in breast cancer cells by up-regulating miR-324-3p to inhibit GPX4 expression