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These systems achieve controlled drug release by modulating the physicochemical properties of polymers, such as solubility, release kinetics, and targeting capabilities, thereby enhancing therapeutic efficacy and reducing adverse effects (Gonzalez et al., 2023)

Research progress on pharmacological effects and bioavailability of berberine

Oxidative stress stimulates invasive potential in rat C6 and human U-87 MG glioblastoma cells via activation and cross-talk between PKM2, ENPP2 and APE1 enzymes

Conclusion Our findings imply that BER chitosomes are a viable intranasal delivery tool for the efficient treatment of PD due to their enhanced bioavailability