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While the studys design as an open-label trial warrants consideration when interpreting results, the trial supports the superiority of tirzepatides dual-action mechanism targeting both GIP and GLP-1 receptors, compared to semaglutides single GLP-1 receptor targeting approach

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doi: 10.1038/s41467-019-11953-9 83 LiYRLiJZhaoSDBradfieldJPMentchFDMaggadottirSMet al

The rationale is that combination therapy may more closely replicate the physiological secretion ratio of T4 to T3 (approximately 13:1 by weight), potentially restoring a more physiological FT3/FT4 balance (43)